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Channel Formation and Membrane Deformation via Sterol-Aided Polymorphism of Amphidinol 3

Amphidinol 3 (AM3) is an anti-fungal polyene extracted from a marine dinoflagellate. Here, we examined the ion channel activity and membrane-embedded structure of AM3 using a lipid bilayer method and atomic force microscopy (AFM). AM3 exhibited large-conductance (~1 nS) and non-selective single-chan...

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Detalles Bibliográficos
Autores principales:	Iwamoto, Masayuki, Sumino, Ayumi, Shimada, Eri, Kinoshita, Masanao, Matsumori, Nobuaki, Oiki, Shigetoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589915/ https://www.ncbi.nlm.nih.gov/pubmed/28883505 http://dx.doi.org/10.1038/s41598-017-11135-x

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