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Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A(2) group IIE

Secreted phospholipases A(2)s (sPLA(2)s) are involved in various pathological conditions such as rheumatoid arthritis and cardiovascular disease. Many inhibitors were developed and studied in clinical trials, but none have reached the market yet. This failure may be attributed to the lack of subtype...

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Detalles Bibliográficos
Autores principales: Hou, Shulin, Xu, Tingting, Xu, Jinxin, Qu, Linbing, Xu, Yong, Chen, Ling, Liu, Jinsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589937/
https://www.ncbi.nlm.nih.gov/pubmed/28883454
http://dx.doi.org/10.1038/s41598-017-11219-8