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Structural basis for functional selectivity and ligand recognition revealed by crystal structures of human secreted phospholipase A(2) group IIE
Secreted phospholipases A(2)s (sPLA(2)s) are involved in various pathological conditions such as rheumatoid arthritis and cardiovascular disease. Many inhibitors were developed and studied in clinical trials, but none have reached the market yet. This failure may be attributed to the lack of subtype...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589937/ https://www.ncbi.nlm.nih.gov/pubmed/28883454 http://dx.doi.org/10.1038/s41598-017-11219-8 |