Hysteretic Dynamics of Multi-Stable Early Afterdepolarisations with Repolarisation Reserve Attenuation: A Potential Dynamical Mechanism for Cardiac Arrhythmias

Some cardiovascular and non-cardiovascular drugs frequently cause excessive prolongation of the cardiac action potential (AP) and lead to the development of early afterdepolarisations (EADs), which trigger lethal ventricular arrhythmias. Combining computer simulations in APs with numerical calculati...

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Detalles Bibliográficos
Autores principales: Tsumoto, Kunichika, Kurata, Yasutaka, Furutani, Kazuharu, Kurachi, Yoshihisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589958/
https://www.ncbi.nlm.nih.gov/pubmed/28883639
http://dx.doi.org/10.1038/s41598-017-11355-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589958/
https://www.ncbi.nlm.nih.gov/pubmed/28883639
http://dx.doi.org/10.1038/s41598-017-11355-1

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