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The inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies
BACKGROUND: We used a food-based empirical dietary inflammatory pattern (EDIP) score to investigate whether diets with higher inflammatory potential are associated with increased ovarian cancer risk. METHODS: We followed 186 314 women in the Nurses’ Health Study and Nurses’ Health Study-II, from 198...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589994/ https://www.ncbi.nlm.nih.gov/pubmed/28772285 http://dx.doi.org/10.1038/bjc.2017.246 |
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author | Tabung, Fred K Huang, Tianyi Giovannucci, Edward L Smith-Warner, Stephanie A Tworoger, Shelley S Poole, Elizabeth M |
author_facet | Tabung, Fred K Huang, Tianyi Giovannucci, Edward L Smith-Warner, Stephanie A Tworoger, Shelley S Poole, Elizabeth M |
author_sort | Tabung, Fred K |
collection | PubMed |
description | BACKGROUND: We used a food-based empirical dietary inflammatory pattern (EDIP) score to investigate whether diets with higher inflammatory potential are associated with increased ovarian cancer risk. METHODS: We followed 186 314 women in the Nurses’ Health Study and Nurses’ Health Study-II, from 1984 to 2013, to examine associations between EDIP scores and ovarian cancer risk, using Cox regression analyses. RESULTS: During 3 454 514 person-years of follow-up, 989 ovarian cancer cases were identified. In pooled multivariable-adjusted analyses, higher EDIP scores (more pro-inflammatory diets) were not significantly associated with ovarian cancer risk (HR(quintile5vs1) 0.99; 95% CI: 0.80–1.22; P-trend=0.97). Similarly, we found no evidence of heterogeneity by histologic subtype (P-heterogeneity=0.52) or by tumour aggressiveness (P-heterogeneity=0.63). CONCLUSIONS: In contrast with two previous case-control studies that found a positive association between a literature-derived nutrient-based dietary inflammatory index and ovarian cancer risk, our prospective analyses using a food-based score observed no evidence of an association. |
format | Online Article Text |
id | pubmed-5589994 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-55899942018-09-05 The inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies Tabung, Fred K Huang, Tianyi Giovannucci, Edward L Smith-Warner, Stephanie A Tworoger, Shelley S Poole, Elizabeth M Br J Cancer Epidemiology BACKGROUND: We used a food-based empirical dietary inflammatory pattern (EDIP) score to investigate whether diets with higher inflammatory potential are associated with increased ovarian cancer risk. METHODS: We followed 186 314 women in the Nurses’ Health Study and Nurses’ Health Study-II, from 1984 to 2013, to examine associations between EDIP scores and ovarian cancer risk, using Cox regression analyses. RESULTS: During 3 454 514 person-years of follow-up, 989 ovarian cancer cases were identified. In pooled multivariable-adjusted analyses, higher EDIP scores (more pro-inflammatory diets) were not significantly associated with ovarian cancer risk (HR(quintile5vs1) 0.99; 95% CI: 0.80–1.22; P-trend=0.97). Similarly, we found no evidence of heterogeneity by histologic subtype (P-heterogeneity=0.52) or by tumour aggressiveness (P-heterogeneity=0.63). CONCLUSIONS: In contrast with two previous case-control studies that found a positive association between a literature-derived nutrient-based dietary inflammatory index and ovarian cancer risk, our prospective analyses using a food-based score observed no evidence of an association. Nature Publishing Group 2017-09-05 2017-08-03 /pmc/articles/PMC5589994/ /pubmed/28772285 http://dx.doi.org/10.1038/bjc.2017.246 Text en Copyright © 2017 Cancer Research UK http://creativecommons.org/licenses/by-nc-sa/4.0/ From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 4.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/ |
spellingShingle | Epidemiology Tabung, Fred K Huang, Tianyi Giovannucci, Edward L Smith-Warner, Stephanie A Tworoger, Shelley S Poole, Elizabeth M The inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies |
title | The inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies |
title_full | The inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies |
title_fullStr | The inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies |
title_full_unstemmed | The inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies |
title_short | The inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies |
title_sort | inflammatory potential of diet and ovarian cancer risk: results from two prospective cohort studies |
topic | Epidemiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5589994/ https://www.ncbi.nlm.nih.gov/pubmed/28772285 http://dx.doi.org/10.1038/bjc.2017.246 |
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