GNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi

BACKGROUND: Mutations in GNAQ/11 genes are considered an early event in the development of uveal melanoma that may derive from a pre-existing nevus. The Hippo pathway, by way of YAP activation, rather than MAP kinase, has a role in the oncogenic capacity of GNAQ/11 mutations. METHODS: We investigate...

Descripción completa

Detalles Bibliográficos
Autores principales: Vader, M J C, Madigan, M C, Versluis, M, Suleiman, H M, Gezgin, G, Gruis, N A, Out-Luiting, J J, Bergman, W, Verdijk, R M, Jager, M J, van der Velden, P A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Genetics & Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590000/
https://www.ncbi.nlm.nih.gov/pubmed/28809862
http://dx.doi.org/10.1038/bjc.2017.259

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590000/
https://www.ncbi.nlm.nih.gov/pubmed/28809862
http://dx.doi.org/10.1038/bjc.2017.259

Ejemplares similares