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GNAQ and GNA11 mutations and downstream YAP activation in choroidal nevi

BACKGROUND: Mutations in GNAQ/11 genes are considered an early event in the development of uveal melanoma that may derive from a pre-existing nevus. The Hippo pathway, by way of YAP activation, rather than MAP kinase, has a role in the oncogenic capacity of GNAQ/11 mutations. METHODS: We investigate...

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Detalles Bibliográficos
Autores principales:	Vader, M J C, Madigan, M C, Versluis, M, Suleiman, H M, Gezgin, G, Gruis, N A, Out-Luiting, J J, Bergman, W, Verdijk, R M, Jager, M J, van der Velden, P A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Genetics & Genomics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590000/ https://www.ncbi.nlm.nih.gov/pubmed/28809862 http://dx.doi.org/10.1038/bjc.2017.259

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