Effects of Adamantyl Derivatives on Pharmacokinetic Behavior of Paclitaxel in Rats

Paclitaxel (PTX) is one of the most frequently used anticancer agent for treating refractory ovarian cancer, metastatic breast cancer and non-small cell lung cancer. However, its oral administration is impeded by very low bioavailability (<5%) due to the Pglycopprotein (P-gp) efflux pump effect....

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Detalles Bibliográficos
Autores principales: Kim, Kyung Mi, Lee, Kyeong, Jang, Kyusic, Moon, Yae Seul, Lee, Hwa Jeong, Rhie, Sandy Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Applied Pharmacology 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590800/
https://www.ncbi.nlm.nih.gov/pubmed/28173641
http://dx.doi.org/10.4062/biomolther.2016.191

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590800/
https://www.ncbi.nlm.nih.gov/pubmed/28173641
http://dx.doi.org/10.4062/biomolther.2016.191

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