Cargando…
Effects of Adamantyl Derivatives on Pharmacokinetic Behavior of Paclitaxel in Rats
Paclitaxel (PTX) is one of the most frequently used anticancer agent for treating refractory ovarian cancer, metastatic breast cancer and non-small cell lung cancer. However, its oral administration is impeded by very low bioavailability (<5%) due to the Pglycopprotein (P-gp) efflux pump effect....
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Korean Society of Applied Pharmacology
2017
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590800/ https://www.ncbi.nlm.nih.gov/pubmed/28173641 http://dx.doi.org/10.4062/biomolther.2016.191 |