Loss of SPRR3 in ApoE(-/-) mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs

Vascular smooth muscle cells (VSMCs) represent important modulators of plaque stability in advanced lesions. We previously reported that loss of small proline-rich repeat protein 3 (Sprr3), leads to VSMC apoptosis in a PI3K/Akt-dependent manner and accelerates lesion progression. Here, we investigat...

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Detalles Bibliográficos
Autores principales: Lietman, Caressa D., Segedy, Amanda K., Li, Bin, Fazio, Sergio, Atkinson, James B., Linton, MacRae F., Young, Pampee P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590986/
https://www.ncbi.nlm.nih.gov/pubmed/28886156
http://dx.doi.org/10.1371/journal.pone.0184620

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590986/
https://www.ncbi.nlm.nih.gov/pubmed/28886156
http://dx.doi.org/10.1371/journal.pone.0184620

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