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Loss of SPRR3 in ApoE(-/-) mice leads to atheroma vulnerability through Akt dependent and independent effects in VSMCs
Vascular smooth muscle cells (VSMCs) represent important modulators of plaque stability in advanced lesions. We previously reported that loss of small proline-rich repeat protein 3 (Sprr3), leads to VSMC apoptosis in a PI3K/Akt-dependent manner and accelerates lesion progression. Here, we investigat...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590986/ https://www.ncbi.nlm.nih.gov/pubmed/28886156 http://dx.doi.org/10.1371/journal.pone.0184620 |