Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms

Alkylating agents are ubiquitous in our internal and external environments, causing DNA damage that contributes to mutations and cell death that can result in aging, tissue degeneration and cancer. Repair of methylated DNA bases occurs primarily through the base excision repair (BER) pathway, a mult...

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Detalles Bibliográficos
Autores principales: Margulies, Carrie M., Chaim, Isaac Alexander, Mazumder, Aprotim, Criscione, June, Samson, Leona D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590993/
https://www.ncbi.nlm.nih.gov/pubmed/28886188
http://dx.doi.org/10.1371/journal.pone.0184619

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5590993/
https://www.ncbi.nlm.nih.gov/pubmed/28886188
http://dx.doi.org/10.1371/journal.pone.0184619

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