Cargando…

Experimental Vaccine Induces Th1-driven Immune Responses and Resistance to Neisseria gonorrhoeae Infection in a Murine Model

Female mice were immunized intravaginally with gonococcal outer membrane vesicles (OMV) plus microencapsulated IL-12, and challenged using an established model of genital infection with Neisseria gonorrhoeae. Whereas sham-immunized and control animals cleared the infection in 10–13 days, those immun...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Yingru, Hammer, Laura A., Liu, Wensheng, Hobbs, Marcia M., Zielke, Ryszard A., Sikora, Aleksandra E., Jerse, Ann E., Egilmez, Nejat K., Russell, Michael W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591041/ https://www.ncbi.nlm.nih.gov/pubmed/28272393 http://dx.doi.org/10.1038/mi.2017.11

Ejemplares similares

Lipid-Modified Azurin of Neisseria gonorrhoeae Is Not Surface Exposed and Does Not Interact With the Nitrite Reductase AniA
por: Baarda, Benjamin I., et al.
Publicado: (2018)

Neisseria gonorrhoeae MlaA influences gonococcal virulence and membrane vesicle production
por: Baarda, Benjamin I., et al.
Publicado: (2019)

Comprehensive Bioinformatic Assessments of the Variability of Neisseria gonorrhoeae Vaccine Candidates
por: Baarda, Benjamin I., et al.
Publicado: (2021)

Intravaginal Administration of Interleukin 12 during Genital Gonococcal Infection in Mice Induces Immunity to Heterologous Strains of Neisseria gonorrhoeae
por: Liu, Yingru, et al.
Publicado: (2018)

SliC is a surface-displayed lipoprotein that is required for the anti-lysozyme strategy during Neisseria gonorrhoeae infection
por: Zielke, Ryszard A., et al.
Publicado: (2018)

Critical role of Th17 responses in a murine model of Neisseria gonorrhoeae genital infection
por: Feinen, Brandon, et al.
Publicado: (2010)

Microencapsulated IL-12 Drives Genital Tract Immune Responses to Intranasal Gonococcal Outer Membrane Vesicle Vaccine and Induces Resistance to Vaginal Infection with Diverse Strains of Neisseria gonorrhoeae
por: Liu, Yingru, et al.
Publicado: (2022)

Editorial: Immunity to Neisseria gonorrhoeae
por: Russell, Michael W., et al.
Publicado: (2020)

The Neisseria gonorrhoeae Obg protein is an essential ribosome-associated GTPase and a potential drug target
por: Zielke, Ryszard A., et al.
Publicado: (2015)

Suppression of host adaptive immune responses by Neisseria gonorrhoeae: role of interleukin 10 and type 1 regulatory T cells
por: Liu, Yingru, et al.
Publicado: (2013)

Functional and structural studies on the Neisseria gonorrhoeae GmhA, the first enzyme in the glycero‐manno‐heptose biosynthesis pathways, demonstrate a critical role in lipooligosaccharide synthesis and gonococcal viability
por: Wierzbicki, Igor H., et al.
Publicado: (2017)

Functional Characterization of Antibodies against Neisseria gonorrhoeae Opacity Protein Loops
por: Cole, Jessica G., et al.
Publicado: (2009)

Diversion of the Immune Response to Neisseria gonorrhoeae from Th17 to Th1/Th2 by Treatment with Anti-Transforming Growth Factor β Antibody Generates Immunological Memory and Protective Immunity
por: Liu, Yingru, et al.
Publicado: (2011)

Lipid A’s Structure Mediates Neisseria gonorrhoeae Fitness during Experimental Infection of Mice and Men
por: Hobbs, Marcia M., et al.
Publicado: (2013)

Experimental Gonococcal Infection in Male Volunteers: Cumulative Experience with Neisseria gonorrhoeae Strains FA1090 and MS11mkC
por: Hobbs, Marcia M., et al.
Publicado: (2011)

Proteomics of Neisseria gonorrhoeae: the treasure hunt for countermeasures against an old disease
por: Baarda, Benjamin I., et al.
Publicado: (2015)

Challenges and Controversies Concerning Neisseria gonorrhoeae-Neutrophil Interactions in Pathogenesis
por: Criss, Alison K., et al.
Publicado: (2021)

New Concepts in Immunity to Neisseria Gonorrhoeae: Innate Responses and Suppression of Adaptive Immunity Favor the Pathogen, Not the Host
por: Liu, Yingru, et al.
Publicado: (2011)

Neisseria gonorrhoeae selectively suppresses the development of Th1 and Th2 cells, and enhances Th17 cell responses, through TGF-β-dependent mechanisms
por: Liu, Yingru, et al.
Publicado: (2012)

Neisseria gonorrhoeae Coinfection during Chlamydia muridarum Genital Latency Does Not Modulate Murine Vaginal Bacterial Shedding
por: Onorini, Delia, et al.
Publicado: (2023)

Structure‐based design of ferritin nanoparticle immunogens displaying antigenic loops of Neisseria gonorrhoeae
por: Wang, Liqin, et al.
Publicado: (2017)

Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections
por: Jerse, Ann E., et al.
Publicado: (2011)

Neisseria gonorrhoeae
por: Ehrhard, Ingrid
Publicado: (2009)

Neisseria gonorrhoeae Infections
por: Suay-García, Beatriz, et al.
Publicado: (2020)

Contrasting Roles of IL-22 and IL-17 in Murine Genital Tract Infection by Neisseria gonorrhoeae
por: Feinen, Brandon, et al.
Publicado: (2012)

Resistance of Neisseria Gonorrhoeae to Neutrophils
por: Johnson, M. Brittany, et al.
Publicado: (2011)

Fluoroquinolone resistance in Neisseria gonorrhoeae.
por: Knapp, J S, et al.
Publicado: (1997)

Conjugative Plasmids of Neisseria gonorrhoeae
por: Pachulec, Emilia, et al.
Publicado: (2010)

Molecular Pathogenesis of Neisseria Gonorrhoeae
por: Cornelissen, Cynthia N.
Publicado: (2011)

Cephalosporin Resistance in Neisseria gonorrhoeae
por: Bala, Manju, et al.
Publicado: (2010)

The comparative population genetics of Neisseria meningitidis and Neisseria gonorrhoeae
por: Vigué, Lucile, et al.
Publicado: (2019)

Drug-resistant Neisseria gonorrhoeae in Michigan
por: Macomber, Kathryn E., et al.
Publicado: (2005)

A Culture Collection of 50 Neisseria gonorrhoeae Isolates
por: Liu, H., et al.
Publicado: (2020)

Sequence Features Contributing to Chromosomal Rearrangements in Neisseria gonorrhoeae
por: Spencer-Smith, Russell, et al.
Publicado: (2012)

Genomic Diversity and Chromosomal Rearrangements in Neisseria gonorrhoeae and Neisseria meningitidis
por: Shaskolskiy, Boris, et al.
Publicado: (2022)

Neisseria gonorrhoeae Meningitis in Pregnant Adolescent
por: Martín, Maria C., et al.
Publicado: (2008)

Ceftriaxone-Resistant Neisseria gonorrhoeae, Japan
por: Ohnishi, Makoto, et al.
Publicado: (2011)

Performance of tests for identification of Neisseria gonorrhoeae
por: Kulkarni, Sangeeta, et al.
Publicado: (2015)

Future Prospects for Neisseria gonorrhoeae Treatment
por: Suay-García, Beatriz, et al.
Publicado: (2018)

Neisseria Gonorrhoeae Spontaneous Bacterial Peritonitis
por: Mwandia, George, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_unkmjnsnf1jhmr2k9p7vqp9eha