Metformin Improves Endothelial Function and Reduces Blood Pressure in Diabetic Spontaneously Hypertensive Rats Independent from Glycemia Control: Comparison to Vildagliptin

Metformin confers vascular benefits beyond glycemia control, possibly via pleiotropic effects on endothelial function. In type-1-diabetes-mellitus (T1DM-)patients metformin improved flow-mediated dilation but also increased prostaglandin(PG)-F(2α), a known endothelial-contracting factor. To explain...

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Detalles Bibliográficos
Autores principales: Hamidi Shishavan, Mahdi, Henning, Robert H., van Buiten, Azuwerus, Goris, Maaike, Deelman, Leo E., Buikema, Hendrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591199/
https://www.ncbi.nlm.nih.gov/pubmed/28887562
http://dx.doi.org/10.1038/s41598-017-11430-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591199/
https://www.ncbi.nlm.nih.gov/pubmed/28887562
http://dx.doi.org/10.1038/s41598-017-11430-7

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