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Creation and Initial Characterization of Isogenic Helicobacter pylori CagA EPIYA Variants Reveals Differential Activation of Host Cell Signaling Pathways

The polymorphic CagA toxin is associated with Helicobacter pylori-induced disease. Previous data generated using non-isogenic strains and transfection models suggest that variation surrounding the C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs as well as the number of EPIYA motifs influence disease o...

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Detalles Bibliográficos
Autores principales: Bridge, Dacie R., Blum, Faith C., Jang, Sungil, Kim, Jinmoon, Cha, Jeong-Heon, Merrell, D. Scott
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591203/
https://www.ncbi.nlm.nih.gov/pubmed/28887533
http://dx.doi.org/10.1038/s41598-017-11382-y