LNA effects on DNA binding and conformation: from single strand to duplex and triplex structures

The anti-gene strategy is based on sequence-specific recognition of double-strand DNA by triplex forming (TFOs) or DNA strand invading oligonucleotides to modulate gene expression. To be efficient, the oligonucleotides (ONs) should target DNA selectively, with high affinity. Here we combined hybridi...

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Detalles Bibliográficos
Autores principales: Pabon-Martinez, Y. Vladimir, Xu, You, Villa, Alessandra, Lundin, Karin E., Geny, Sylvain, Nguyen, Chi-Hung, Pedersen, Erik B., Jørgensen, Per T., Wengel, Jesper, Nilsson, Lennart, Smith, C. I. Edvard, Zain, Rula
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591256/
https://www.ncbi.nlm.nih.gov/pubmed/28887512
http://dx.doi.org/10.1038/s41598-017-09147-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591256/
https://www.ncbi.nlm.nih.gov/pubmed/28887512
http://dx.doi.org/10.1038/s41598-017-09147-8

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