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The intestinal phosphate transporter NaPi-IIb (Slc34a2) is required to protect bone during dietary phosphate restriction

NaPi-IIb/Slc34a2 is a Na(+)-dependent phosphate transporter that accounts for the majority of active phosphate transport into intestinal epithelial cells. Its abundance is regulated by dietary phosphate, being high during dietary phosphate restriction. Intestinal ablation of NaPi-IIb in mice leads t...

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Detalles Bibliográficos
Autores principales: Knöpfel, Thomas, Pastor-Arroyo, Eva M., Schnitzbauer, Udo, Kratschmar, Denise V., Odermatt, Alex, Pellegrini, Giovanni, Hernando, Nati, Wagner, Carsten A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591270/
https://www.ncbi.nlm.nih.gov/pubmed/28887454
http://dx.doi.org/10.1038/s41598-017-10390-2