CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination

In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA. CSR is initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues at t...

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Detalles Bibliográficos
Autores principales: Marina-Zárate, Ester, Pérez-García, Arantxa, Ramiro, Almudena R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591319/
https://www.ncbi.nlm.nih.gov/pubmed/28928744
http://dx.doi.org/10.3389/fimmu.2017.01076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591319/
https://www.ncbi.nlm.nih.gov/pubmed/28928744
http://dx.doi.org/10.3389/fimmu.2017.01076

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