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CCCTC-Binding Factor Locks Premature IgH Germline Transcription and Restrains Class Switch Recombination

In response to antigenic stimulation B cells undergo class switch recombination (CSR) at the immunoglobulin heavy chain (IgH) to replace the primary IgM/IgD isotypes by IgG, IgE, or IgA. CSR is initiated by activation-induced cytidine deaminase (AID) through the deamination of cytosine residues at t...

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Detalles Bibliográficos
Autores principales:	Marina-Zárate, Ester, Pérez-García, Arantxa, Ramiro, Almudena R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591319/ https://www.ncbi.nlm.nih.gov/pubmed/28928744 http://dx.doi.org/10.3389/fimmu.2017.01076

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