Augmentation of intracellular iron using iron sucrose enhances the toxicity of pharmacological ascorbate in colon cancer cells

Pharmacological doses (> 1 mM) of ascorbate (a.k.a., vitamin C) have been shown to selectively kill cancer cells through a mechanism that is dependent on the generation of H(2)O(2) at doses that are safely achievable in humans using intravenous administration. The process by which ascorbate oxidi...

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Detalles Bibliográficos
Autores principales: Brandt, Kristin E., Falls, Kelly C., Schoenfeld, Joshua D., Rodman, Samuel N., Gu, Zhimin, Zhan, Fenghuang, Cullen, Joseph J., Wagner, Brett A., Buettner, Garry R., Allen, Bryan G., Berg, Daniel J., Spitz, Douglas R., Fath, Melissa A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591450/
https://www.ncbi.nlm.nih.gov/pubmed/28886484
http://dx.doi.org/10.1016/j.redox.2017.08.017

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591450/
https://www.ncbi.nlm.nih.gov/pubmed/28886484
http://dx.doi.org/10.1016/j.redox.2017.08.017

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