Genome editing of the HIV co-receptors CCR5 and CXCR4 by CRISPR-Cas9 protects CD4(+) T cells from HIV-1 infection

BACKGROUND: The main approach to treat HIV-1 infection is combination antiretroviral therapy (cART). Although cART is effective in reducing HIV-1 viral load and controlling disease progression, it has many side effects, and is expensive for HIV-1 infected patients who must remain on lifetime treatme...

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Detalles Bibliográficos
Autores principales: Liu, Zhepeng, Chen, Shuliang, Jin, Xu, Wang, Qiankun, Yang, Kongxiang, Li, Chenlin, Xiao, Qiaoqiao, Hou, Panpan, Liu, Shuai, Wu, Shaoshuai, Hou, Wei, Xiong, Yong, Kong, Chunyan, Zhao, Xixian, Wu, Li, Li, Chunmei, Sun, Guihong, Guo, Deyin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591563/
https://www.ncbi.nlm.nih.gov/pubmed/28904745
http://dx.doi.org/10.1186/s13578-017-0174-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591563/
https://www.ncbi.nlm.nih.gov/pubmed/28904745
http://dx.doi.org/10.1186/s13578-017-0174-2

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