Population Pharmacokinetics of Cladribine in Patients with Multiple Sclerosis

PURPOSE: The aims of this study were to characterize the concentration–time course of cladribine (CdA) and its main metabolite 2-chloroadenine (CAde), estimate interindividual variability in pharmacokinetics (PK), and identify covariates explaining variability in the PK of CdA. METHODS: This populat...

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Detalles Bibliográficos
Autores principales: Savic, Radojka M., Novakovic, Ana M., Ekblom, Marianne, Munafo, Alain, Karlsson, Mats O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591805/
https://www.ncbi.nlm.nih.gov/pubmed/28255849
http://dx.doi.org/10.1007/s40262-017-0516-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591805/
https://www.ncbi.nlm.nih.gov/pubmed/28255849
http://dx.doi.org/10.1007/s40262-017-0516-6

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