Successful Use of [(14)C]Paracetamol Microdosing to Elucidate Developmental Changes in Drug Metabolism

BACKGROUND: We previously showed the practical and ethical feasibility of using [(14)C]-microdosing for pharmacokinetic studies in children. We now aimed to show that this approach can be used to elucidate developmental changes in drug metabolism, more specifically, glucuronidation and sulfation, us...

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Detalles Bibliográficos
Autores principales: Mooij, Miriam G., van Duijn, Esther, Knibbe, Catherijne A. J., Allegaert, Karel, Windhorst, Albert D., van Rosmalen, Joost, Hendrikse, N. Harry, Tibboel, Dick, Vaes, Wouter H. J., de Wildt, Saskia N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591809/
https://www.ncbi.nlm.nih.gov/pubmed/28155137
http://dx.doi.org/10.1007/s40262-017-0508-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591809/
https://www.ncbi.nlm.nih.gov/pubmed/28155137
http://dx.doi.org/10.1007/s40262-017-0508-6

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