Effect of Short-Term Fasting on Systemic Cytochrome P450-Mediated Drug Metabolism in Healthy Subjects: A Randomized, Controlled, Crossover Study Using a Cocktail Approach

BACKGROUND AND OBJECTIVE: Short-term fasting can alter drug exposure but it is unknown whether this is an effect of altered oral bioavailability and/or systemic clearance. Therefore, the aim of our study was to assess the effect of short-term fasting on oral bioavailability and systemic clearance of...

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Detalles Bibliográficos
Autores principales: Lammers, Laureen A., Achterbergh, Roos, van Schaik, Ron H. N., Romijn, Johannes A., Mathôt, Ron A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2017
Materias:
Original Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591816/
https://www.ncbi.nlm.nih.gov/pubmed/28229374
http://dx.doi.org/10.1007/s40262-017-0515-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5591816/
https://www.ncbi.nlm.nih.gov/pubmed/28229374
http://dx.doi.org/10.1007/s40262-017-0515-7

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