Wnt-Dependent Inactivation of the Groucho/TLE Co-repressor by the HECT E3 Ubiquitin Ligase Hyd/UBR5

Extracellular signals are transduced to the cell nucleus by effectors that bind to enhancer complexes to operate transcriptional switches. For example, the Wnt enhanceosome is a multiprotein complex associated with Wnt-responsive enhancers through T cell factors (TCF) and kept silent by Groucho/TLE...

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Detalles Bibliográficos
Autores principales: Flack, Joshua E., Mieszczanek, Juliusz, Novcic, Nikola, Bienz, Mariann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592244/
https://www.ncbi.nlm.nih.gov/pubmed/28689657
http://dx.doi.org/10.1016/j.molcel.2017.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592244/
https://www.ncbi.nlm.nih.gov/pubmed/28689657
http://dx.doi.org/10.1016/j.molcel.2017.06.009

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