Rho GTPases as therapeutic targets in cancer (Review)

Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Cardama, G.A., Gonzalez, N., Maggio, J., Menna, P. Lorenzano, Gomez, D.E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592879/
https://www.ncbi.nlm.nih.gov/pubmed/28848995
http://dx.doi.org/10.3892/ijo.2017.4093
_version_ 1783262951282573312
author Cardama, G.A.
Gonzalez, N.
Maggio, J.
Menna, P. Lorenzano
Gomez, D.E.
author_facet Cardama, G.A.
Gonzalez, N.
Maggio, J.
Menna, P. Lorenzano
Gomez, D.E.
author_sort Cardama, G.A.
collection PubMed
description Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of the present review is to describe the cellular functions regulated by these proteins with focus in deregulated signals present in malignant tumors. Finally, we describe the state of the art in search of different experimental therapeutic strategies with Rho GTPases as molecular targets.
format Online
Article
Text
id pubmed-5592879
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher D.A. Spandidos
record_format MEDLINE/PubMed
spelling pubmed-55928792017-09-22 Rho GTPases as therapeutic targets in cancer (Review) Cardama, G.A. Gonzalez, N. Maggio, J. Menna, P. Lorenzano Gomez, D.E. Int J Oncol Articles Rho GTPases are key molecular switches controlling the transduction of external signals to cytoplasmic and nuclear effectors. In the last few years, the development of genetic and pharmacological tools has allowed a more precise definition of the specific roles of Rho GTPases in cancer. The aim of the present review is to describe the cellular functions regulated by these proteins with focus in deregulated signals present in malignant tumors. Finally, we describe the state of the art in search of different experimental therapeutic strategies with Rho GTPases as molecular targets. D.A. Spandidos 2017-08-09 /pmc/articles/PMC5592879/ /pubmed/28848995 http://dx.doi.org/10.3892/ijo.2017.4093 Text en Copyright: © Cardama et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Articles
Cardama, G.A.
Gonzalez, N.
Maggio, J.
Menna, P. Lorenzano
Gomez, D.E.
Rho GTPases as therapeutic targets in cancer (Review)
title Rho GTPases as therapeutic targets in cancer (Review)
title_full Rho GTPases as therapeutic targets in cancer (Review)
title_fullStr Rho GTPases as therapeutic targets in cancer (Review)
title_full_unstemmed Rho GTPases as therapeutic targets in cancer (Review)
title_short Rho GTPases as therapeutic targets in cancer (Review)
title_sort rho gtpases as therapeutic targets in cancer (review)
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592879/
https://www.ncbi.nlm.nih.gov/pubmed/28848995
http://dx.doi.org/10.3892/ijo.2017.4093
work_keys_str_mv AT cardamaga rhogtpasesastherapeutictargetsincancerreview
AT gonzalezn rhogtpasesastherapeutictargetsincancerreview
AT maggioj rhogtpasesastherapeutictargetsincancerreview
AT mennaplorenzano rhogtpasesastherapeutictargetsincancerreview
AT gomezde rhogtpasesastherapeutictargetsincancerreview

Ejemplares similares