Reduced Protein Expression in a Virus Attenuated by Codon Deoptimization

A general means of viral attenuation involves the extensive recoding of synonymous codons in the viral genome. The mechanistic underpinnings of this approach remain unclear, however. Using quantitative proteomics and RNA sequencing, we explore the molecular basis of attenuation in a strain of bacter...

Descripción completa

Detalles Bibliográficos
Autores principales: Jack, Benjamin R., Boutz, Daniel R., Paff, Matthew L., Smith, Bartram L., Bull, James J., Wilke, Claus O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592923/
https://www.ncbi.nlm.nih.gov/pubmed/28698233
http://dx.doi.org/10.1534/g3.117.041020

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592923/
https://www.ncbi.nlm.nih.gov/pubmed/28698233
http://dx.doi.org/10.1534/g3.117.041020

Ejemplares similares