Two Types of Etiological Mutation in the Limb-Specific Enhancer of Shh

An enhancer named MFCS1 regulates Sonic hedgehog (Shh) expression in the posterior mesenchyme of limb buds. Several mutations in MFCS1 induce ectopic Shh expression in the anterior limb bud, and these result in preaxial polydactyly (PPD). However, the molecular basis of ectopic Shh expression remain...

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Detalles Bibliográficos
Autores principales: Amano, Takanori, Sagai, Tomoko, Seki, Ryohei, Shiroishi, Toshihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Genetics Society of America 2017
Materias:
Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592926/
https://www.ncbi.nlm.nih.gov/pubmed/28710291
http://dx.doi.org/10.1534/g3.117.044669

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5592926/
https://www.ncbi.nlm.nih.gov/pubmed/28710291
http://dx.doi.org/10.1534/g3.117.044669

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