Intra‐Target Microdosing – A Novel Drug Development Approach: Proof of Concept, Safety, and Feasibility Study in Humans

Intra‐Target Microdosing (ITM) is a novel drug development approach aimed at increasing the efficiency of first‐in‐human (FIH) testing of new molecular entities (NMEs). ITM combines intra‐target drug delivery and “microdosing,” the subpharmacological systemic exposure. We hypothesized that when the...

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Detalles Bibliográficos
Autores principales: Burt, T, MacLeod, D, Lee, K, Santoro, A, DeMasi, DK, Hawk, T, Feinglos, M, Rowland, M, Noveck, RJ
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593161/
https://www.ncbi.nlm.nih.gov/pubmed/28689370
http://dx.doi.org/10.1111/cts.12477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593161/
https://www.ncbi.nlm.nih.gov/pubmed/28689370
http://dx.doi.org/10.1111/cts.12477

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