Does Secretory Clearance Follow Glomerular Filtration Rate in Chronic Kidney Diseases? Reconsidering the Intact Nephron Hypothesis

Drug‐dose modification in chronic kidney disease (CKD) utilizes glomerular filtration rate (GFR) with the implicit assumption that multiple renal excretory processes decline in parallel as CKD progresses. We compiled published pharmacokinetic data to evaluate if GFR predicts renal clearance changes...

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Detalles Bibliográficos
Autores principales: Chapron, A, Shen, DD, Kestenbaum, BR, Robinson‐Cohen, C, Himmelfarb, J, Yeung, CK
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593164/
https://www.ncbi.nlm.nih.gov/pubmed/28675584
http://dx.doi.org/10.1111/cts.12481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593164/
https://www.ncbi.nlm.nih.gov/pubmed/28675584
http://dx.doi.org/10.1111/cts.12481

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