New Paradigm for Translational Modeling to Predict Long‐term Tuberculosis Treatment Response

Disappointing results of recent tuberculosis chemotherapy trials suggest that knowledge gained from preclinical investigations was not utilized to maximal effect. A mouse‐to‐human translational pharmacokinetics (PKs) – pharmacodynamics (PDs) model built on a rich mouse database may improve clinical...

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Detalles Bibliográficos
Autores principales: Bartelink, IH, Zhang, N, Keizer, RJ, Strydom, N, Converse, PJ, Dooley, KE, Nuermberger, EL, Savic, RM
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593171/
https://www.ncbi.nlm.nih.gov/pubmed/28561946
http://dx.doi.org/10.1111/cts.12472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593171/
https://www.ncbi.nlm.nih.gov/pubmed/28561946
http://dx.doi.org/10.1111/cts.12472

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