Regulation of the glucocorticoid receptor via a BET-dependent enhancer drives antiandrogen resistance in prostate cancer

In prostate cancer, resistance to the antiandrogen enzalutamide (Enz) can occur through bypass of androgen receptor (AR) blockade by the glucocorticoid receptor (GR). In contrast to fixed genomic alterations, here we show that GR-mediated antiandrogen resistance is adaptive and reversible due to reg...

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Detalles Bibliográficos
Autores principales: Shah, Neel, Wang, Ping, Wongvipat, John, Karthaus, Wouter R, Abida, Wassim, Armenia, Joshua, Rockowitz, Shira, Drier, Yotam, Bernstein, Bradley E, Long, Henry W, Freedman, Matthew L, Arora, Vivek K, Zheng, Deyou, Sawyers, Charles L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593504/
https://www.ncbi.nlm.nih.gov/pubmed/28891793
http://dx.doi.org/10.7554/eLife.27861

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593504/
https://www.ncbi.nlm.nih.gov/pubmed/28891793
http://dx.doi.org/10.7554/eLife.27861

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