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The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning
Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood. Here we demonstrate that the E3 ubiquitin ligase IDOL determines synaptic ApoER2 protein levels...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593505/ https://www.ncbi.nlm.nih.gov/pubmed/28891791 http://dx.doi.org/10.7554/eLife.29178 |
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author | Gao, Jie Marosi, Mate Choi, Jinkuk Achiro, Jennifer M Kim, Sangmok Li, Sandy Otis, Klara Martin, Kelsey C Portera-Cailliau, Carlos Tontonoz, Peter |
author_facet | Gao, Jie Marosi, Mate Choi, Jinkuk Achiro, Jennifer M Kim, Sangmok Li, Sandy Otis, Klara Martin, Kelsey C Portera-Cailliau, Carlos Tontonoz, Peter |
author_sort | Gao, Jie |
collection | PubMed |
description | Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood. Here we demonstrate that the E3 ubiquitin ligase IDOL determines synaptic ApoER2 protein levels in response to neuronal activation and regulates dendritic spine morphogenesis and plasticity. IDOL-dependent changes in ApoER2 abundance modulate dendritic filopodia initiation and synapse maturation. Loss of IDOL in neurons results in constitutive overexpression of ApoER2 and is associated with impaired activity-dependent structural remodeling of spines and defective LTP in primary neuron cultures and hippocampal slices. IDOL-deficient mice show profound impairment in experience-dependent reorganization of synaptic circuits in the barrel cortex, as well as diminished spatial and associative learning. These results identify control of lipoprotein receptor abundance by IDOL as a post-transcriptional mechanism underlying the structural and functional plasticity of synapses and neural circuits. |
format | Online Article Text |
id | pubmed-5593505 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-55935052017-09-19 The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning Gao, Jie Marosi, Mate Choi, Jinkuk Achiro, Jennifer M Kim, Sangmok Li, Sandy Otis, Klara Martin, Kelsey C Portera-Cailliau, Carlos Tontonoz, Peter eLife Cell Biology Neuronal ApoE receptors are linked to learning and memory, but the pathways governing their abundance, and the mechanisms by which they affect the function of neural circuits are incompletely understood. Here we demonstrate that the E3 ubiquitin ligase IDOL determines synaptic ApoER2 protein levels in response to neuronal activation and regulates dendritic spine morphogenesis and plasticity. IDOL-dependent changes in ApoER2 abundance modulate dendritic filopodia initiation and synapse maturation. Loss of IDOL in neurons results in constitutive overexpression of ApoER2 and is associated with impaired activity-dependent structural remodeling of spines and defective LTP in primary neuron cultures and hippocampal slices. IDOL-deficient mice show profound impairment in experience-dependent reorganization of synaptic circuits in the barrel cortex, as well as diminished spatial and associative learning. These results identify control of lipoprotein receptor abundance by IDOL as a post-transcriptional mechanism underlying the structural and functional plasticity of synapses and neural circuits. eLife Sciences Publications, Ltd 2017-09-11 /pmc/articles/PMC5593505/ /pubmed/28891791 http://dx.doi.org/10.7554/eLife.29178 Text en © 2017, Gao et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Cell Biology Gao, Jie Marosi, Mate Choi, Jinkuk Achiro, Jennifer M Kim, Sangmok Li, Sandy Otis, Klara Martin, Kelsey C Portera-Cailliau, Carlos Tontonoz, Peter The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning |
title | The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning |
title_full | The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning |
title_fullStr | The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning |
title_full_unstemmed | The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning |
title_short | The E3 ubiquitin ligase IDOL regulates synaptic ApoER2 levels and is important for plasticity and learning |
title_sort | e3 ubiquitin ligase idol regulates synaptic apoer2 levels and is important for plasticity and learning |
topic | Cell Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593505/ https://www.ncbi.nlm.nih.gov/pubmed/28891791 http://dx.doi.org/10.7554/eLife.29178 |
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