Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits

Transient receptor potential melastatin 3 (TRPM3) channels are activated by heat, and chemical ligands such as pregnenolone sulphate (PregS) and CIM0216. Here, we show that activation of receptors coupled to heterotrimeric Gi/o proteins inhibits TRPM3 channels. This inhibition was alleviated by co-e...

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Detalles Bibliográficos
Autores principales: Badheka, Doreen, Yudin, Yevgen, Borbiro, Istvan, Hartle, Cassandra M, Yazici, Aysenur, Mirshahi, Tooraj, Rohacs, Tibor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593506/
https://www.ncbi.nlm.nih.gov/pubmed/28829742
http://dx.doi.org/10.7554/eLife.26147

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593506/
https://www.ncbi.nlm.nih.gov/pubmed/28829742
http://dx.doi.org/10.7554/eLife.26147

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