Resistance to CTLA-4 checkpoint inhibition reversed through selective elimination of granulocytic myeloid cells

PURPOSE: Local immunosuppression remains a critical problem that limits clinically meaningful response to checkpoint inhibition in patients with head and neck cancer. Here, we assessed the impact of MDSC elimination on responses to CTLA-4 checkpoint inhibition. EXPERIMENTAL DESIGN: Murine syngeneic...

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Detalles Bibliográficos
Autores principales: Clavijo, Paul E., Moore, Ellen C., Chen, Jianhong, Davis, Ruth J., Friedman, Jay, Kim, Young, Van Waes, Carter, Chen, Zhong, Allen, Clint T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593525/
https://www.ncbi.nlm.nih.gov/pubmed/28915554
http://dx.doi.org/10.18632/oncotarget.18437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593525/
https://www.ncbi.nlm.nih.gov/pubmed/28915554
http://dx.doi.org/10.18632/oncotarget.18437

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