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Loss of p16(INK4A) stimulates aberrant mitochondrial biogenesis through a CDK4/Rb-independent pathway

The tumor suppressor p16INK4A (p16) inhibits cell cycle progression through the CDK4/Rb pathway. We have previously shown that p16 regulates cellular oxidative stress, independent of its role in cell cycle control. We investigated whether loss of p16 had a direct impact on the mitochondria. We found...

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Detalles Bibliográficos
Autores principales: Tyagi, Ethika, Liu, Bin, Li, Chelsea, Liu, Tong, Rutter, Jared, Grossman, Douglas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593528/
https://www.ncbi.nlm.nih.gov/pubmed/28915557
http://dx.doi.org/10.18632/oncotarget.19862