Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a KRAS-driven cancer with a high incidence of metastasis and an overall poor prognosis. Previous work in a genetically engineered mouse model of PDAC showed glucose metabolism to be important for maintaining tumor growth. Multiple glycolytic enzymes, includ...

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Detalles Bibliográficos
Autores principales: Anderson, Marybeth, Marayati, Raoud, Moffitt, Richard, Yeh, Jen Jen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593546/
https://www.ncbi.nlm.nih.gov/pubmed/28915575
http://dx.doi.org/10.18632/oncotarget.9760

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593546/
https://www.ncbi.nlm.nih.gov/pubmed/28915575
http://dx.doi.org/10.18632/oncotarget.9760

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