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Hexokinase 2 promotes tumor growth and metastasis by regulating lactate production in pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC) is a KRAS-driven cancer with a high incidence of metastasis and an overall poor prognosis. Previous work in a genetically engineered mouse model of PDAC showed glucose metabolism to be important for maintaining tumor growth. Multiple glycolytic enzymes, includ...

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Detalles Bibliográficos
Autores principales:	Anderson, Marybeth, Marayati, Raoud, Moffitt, Richard, Yeh, Jen Jen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593546/ https://www.ncbi.nlm.nih.gov/pubmed/28915575 http://dx.doi.org/10.18632/oncotarget.9760

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