Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy

Here, we report new mechanistic insight into how chronic hypoxia increases ‘stemness’ in cancer cells. Using chemical inhibitors, we provide direct experimental evidence that ROS production and mitochondrial biogenesis are both required for the hypoxia-induced propagation of CSCs. More specifically,...

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Detalles Bibliográficos
Autores principales: De Francesco, Ernestina Marianna, Maggiolini, Marcello, Tanowitz, Herbert B., Sotgia, Federica, Lisanti, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593549/
https://www.ncbi.nlm.nih.gov/pubmed/28915578
http://dx.doi.org/10.18632/oncotarget.18445

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593549/
https://www.ncbi.nlm.nih.gov/pubmed/28915578
http://dx.doi.org/10.18632/oncotarget.18445

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