Cargando…

Metformin increases chemo-sensitivity via gene downregulation encoding DNA replication proteins in 5-Fu resistant colorectal cancer cells

Metformin is most widely prescribed for type 2 diabetes. Recently, evidences have shown that metformin has anticancer effects on pancreatic-, colorectal-, ovarian-, and other cancers. Because metformin has less adverse effects and is inexpensive, it could be a useful chemo-therapeutic agent with ant...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kim, Sung-Hee, Kim, Soon-Chan, Ku, Ja-Lok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593582/ https://www.ncbi.nlm.nih.gov/pubmed/28915611 http://dx.doi.org/10.18632/oncotarget.17798

Ejemplares similares

MicroRNA-138 Increases Chemo-Sensitivity of Glioblastoma through Downregulation of Survivin
por: Yoo, Ji-Young, et al.
Publicado: (2021)

Metformin Inhibited Proliferation and Metastasis of Colorectal Cancer and presented a Synergistic Effect on 5-FU
por: Sang, Jing, et al.
Publicado: (2020)

HSP90 inhibition downregulates thymidylate synthase and sensitizes colorectal cancer cell lines to the effect of 5FU-based chemotherapy
por: Nagaraju, Ganji Purnachandra, et al.
Publicado: (2014)

Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug-resistant human hepatocellular carcinoma cells to 5-FU
por: TANG, BO, et al.
Publicado: (2016)

Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug-resistant human hepatocellular carcinoma cells to 5-FU
por: Tang, Bo, et al.
Publicado: (2018)

[Retracted] Downregulation of δ opioid receptor by RNA interference enhances the sensitivity of BEL/FU drug‑resistant human hepatocellular carcinoma cells to 5‑FU
por: Tang, Bo, et al.
Publicado: (2023)

Identification of genes inducing resistance to ionizing radiation in human rectal cancer cell lines: re-sensitization of radio-resistant rectal cancer cells through down regulating NDRG1
por: Kim, Soon-Chan, et al.
Publicado: (2018)

Identification of a Novel Fusion Gene, FAM174A-WWC1, in Early-Onset Colorectal Cancer: Establishment and Characterization of Four Human Cancer Cell Lines from Early-Onset Colorectal Cancers
por: Kim, Soon-Chan, et al.
Publicado: (2019)

Carcinoma-associated fibroblasts affect sensitivity to oxaliplatin and 5FU in colorectal cancer cells
por: Gonçalves-Ribeiro, Samuel, et al.
Publicado: (2016)

Establishment and characterization of 18 human colorectal cancer cell lines
por: Kim, Soon-Chan, et al.
Publicado: (2020)

GALNT6 Knockdown Inhibits the Proliferation and Migration of Colorectal Cancer Cells and Increases the Sensitivity of Cancer Cells to 5-FU
por: Peng, Xiangdong, et al.
Publicado: (2021)

Managing 5FU Cardiotoxicity in Colorectal Cancer Treatment
por: Anaka, Matthew, et al.
Publicado: (2022)

PAR2 Inhibition Enhanced the Sensitivity of Colorectal Cancer Cells to 5-FU and Reduced EMT Signaling
por: Quan, Qiuying, et al.
Publicado: (2019)

Aspirin suppresses chemoresistance and enhances antitumor activity of 5-Fu in 5-Fu-resistant colorectal cancer by abolishing 5-Fu-induced NF-κB activation
por: Fu, Jinbo, et al.
Publicado: (2019)

Group III phospholipase A2 downregulation attenuated survival and metastasis in ovarian cancer and promotes chemo-sensitization
por: Ray, Upasana, et al.
Publicado: (2021)

5-FU promotes stemness of colorectal cancer via p53-mediated WNT/β-catenin pathway activation
por: Cho, Yong-Hee, et al.
Publicado: (2020)

Suppression of pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer to gemcitabine and 5FU, and inhibits the formation of pancreatic cancer stem like cells
por: Cho, Jae Hee, et al.
Publicado: (2017)

Antrodia cinnamomea Enhances Chemo-Sensitivity of 5-FU and Suppresses Colon Tumorigenesis and Cancer Stemness via Up-Regulation of Tumor Suppressor miR-142-3p
por: Huang, Yan-Jiun, et al.
Publicado: (2019)

SORBS1 serves a metastatic role via suppression of AHNAK in colorectal cancer cell lines
por: Cho, Woo-Cheol, et al.
Publicado: (2020)

Ohmic Heating Extract of Vine Pruning Residue Has Anti-Colorectal Cancer Activity and Increases Sensitivity to the Chemotherapeutic Drug 5-FU
por: Jesus, Meirielly S., et al.
Publicado: (2020)

The role of GLI1 for 5-Fu resistance in colorectal cancer
por: Zhang, Lining, et al.
Publicado: (2017)

miR-329 regulates the sensitivity of 5-FU in chemotherapy of colorectal cancer by targeting E2F1
por: Yin, Jie, et al.
Publicado: (2018)

Catechol enhances chemo- and radio-sensitivity by targeting AMPK/Hippo signaling in pancreatic cancer cells
por: Moon, Jeong Yong, et al.
Publicado: (2021)

Chemosensitization of HT29 and HT29-5FU Cell Lines by a Combination of a Multi-Tyrosine Kinase Inhibitor and 5FU Downregulates ABCC1 and Inhibits PIK3CA in Light of Their Importance in Saudi Colorectal Cancer
por: Abdalla, Ashraf N., et al.
Publicado: (2021)

Effects of metformin on colorectal cancer stem cells depend on alterations in glutamine metabolism
por: Kim, Jae Hyun, et al.
Publicado: (2018)

Inhibition of CDK1 Reverses the Resistance of 5-Fu in Colorectal Cancer
por: Zhu, Yiping, et al.
Publicado: (2020)

Establishment and Characterization of Paired Primary and Peritoneal Seeding Human Colorectal Cancer Cell Lines: Identification of Genes That Mediate Metastatic Potential()
por: Kim, Soon-Chan, et al.
Publicado: (2018)

Decreased FANCJ caused by 5FU contributes to the increased sensitivity to oxaliplatin in gastric cancer cells
por: Mori, Ryutaro, et al.
Publicado: (2012)

Curcumol increases the sensitivity of colon cancer to 5-FU by regulating Wnt/β-catenin signaling
por: Gao, Jinfeng, et al.
Publicado: (2021)

Ell3 stimulates 5-FU resistance in a breast cancer cell line
por: Kim, Isaac, et al.
Publicado: (2017)

5-FU Metabolism in Cancer and Orally-Administrable 5-FU Drugs
por: Miura, Koh, et al.
Publicado: (2010)

Knockdown of BAP31 Downregulates Galectin-3 to Inhibit the Wnt/β-Catenin Signaling Pathway to Modulate 5-FU Chemosensitivity and Cancer Stemness in Colorectal Cancer
por: Liu, Jingjing, et al.
Publicado: (2023)

Whole transcriptome sequence data of 5-FU sensitive and 5-FU resistant tumors generated in a mouse model of de novo carcinogenesis
por: Iacovides, Demetris, et al.
Publicado: (2018)

Verbascoside: Identification, Quantification, and Potential Sensitization of Colorectal Cancer Cells to 5-FU by Targeting PI3K/AKT Pathway
por: Attia, Yasmeen M., et al.
Publicado: (2018)

Knockdown of circNRIP1 sensitizes colorectal cancer to 5-FU via sponging miR-532-3p
por: Liu, Fanfan, et al.
Publicado: (2021)

Polydopamine-based Implantable Multifunctional Nanocarpet for Highly Efficient Photothermal-chemo Therapy
por: Tiwari, Arjun Prasad, et al.
Publicado: (2019)

OR01-2 Increased Fracture Risk in Patients Using Insulin Compared to Metformin, Attenuated in Patients Using Combination of Insulin and Metformin: Based on Common Data Models
por: Kim, Kwangsoo, et al.
Publicado: (2022)

Downregulation of IL-18 Expression in the Gut by Metformin-induced Gut Microbiota Modulation
por: Lee, Heetae, et al.
Publicado: (2019)

Hypoxia-mediated radiation and chemo-sensitizing drugs.
por: Adams, G. E.
Publicado: (1984)

Rebound increase in microRNA levels at the end of 5-FU-based therapy in colorectal cancer patients
por: Badr, Doaa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_149oi6k7kfg73ab9ijiq6n70i4