Inhibition of the PI3K/AKT/mTOR pathway activates autophagy and compensatory Ras/Raf/MEK/ERK signalling in prostate cancer

The PI3K/AKT/mTOR pathway is frequently activated in advanced prostate cancer, due to loss of the tumour suppressor PTEN, and is an important axis for drug development. We have assessed the molecular and functional consequences of pathway blockade by inhibiting AKT and mTOR kinases either in combina...

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Detalles Bibliográficos
Autores principales: Butler, Dominika E., Marlein, Christopher, Walker, Hannah F., Frame, Fiona M., Mann, Vincent M., Simms, Matthew S., Davies, Barry R., Collins, Anne T., Maitland, Norman J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593594/
https://www.ncbi.nlm.nih.gov/pubmed/28915623
http://dx.doi.org/10.18632/oncotarget.18082

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593594/
https://www.ncbi.nlm.nih.gov/pubmed/28915623
http://dx.doi.org/10.18632/oncotarget.18082

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