Panobinostat, a histone deacetylase inhibitor, suppresses leptomeningeal seeding in a medulloblastoma animal model

Leptomeningeal seeding is a strong negative prognostic factor for medulloblastoma (MB). The mechanism of leptomeningeal seeding is unclear but may involve epigenetic regulation. In this study, we evaluated the feasibility of a histone deacetylase (HDAC) inhibitor, panobinostat, in the suppression of...

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Detalles Bibliográficos
Autores principales: Phi, Ji Hoon, Choi, Seung Ah, Kwak, Pil Ae, Lee, Ji Yeoun, Wang, Kyu-Chang, Hwang, Do Won, Kim, Seung-Ki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593598/
https://www.ncbi.nlm.nih.gov/pubmed/28915627
http://dx.doi.org/10.18632/oncotarget.18132

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593598/
https://www.ncbi.nlm.nih.gov/pubmed/28915627
http://dx.doi.org/10.18632/oncotarget.18132

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