Reevaluation of ATR signaling in primary resting chronic lymphocytic leukemia cells: evidence for pro-survival or pro-apoptotic function

ATM, primarily activated by DNA double-strand breaks, and ATR, activated by single-stranded DNA, are master regulators of the cellular response to DNA damage. In primary chronic lymphocytic leukemia (CLL) cells, ATR signaling is considered to be switched off due to ATR downregulation. Here, we hypot...

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Detalles Bibliográficos
Autores principales: Beyaert, Maxime, Starczewska, Eliza, Pérez, Ana Cristina González, Vanlangendonck, Nicolas, Saussoy, Pascale, Tilman, Gaëlle, De Leener, Anne, Vekemans, Marie-Christiane, Van Den Neste, Eric, Bontemps, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593612/
https://www.ncbi.nlm.nih.gov/pubmed/28915641
http://dx.doi.org/10.18632/oncotarget.18144

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593612/
https://www.ncbi.nlm.nih.gov/pubmed/28915641
http://dx.doi.org/10.18632/oncotarget.18144

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