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NSC30049 inhibits Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations
The 5-fluorouracil (5-FU) treatment induces DNA damage and stalling of DNA replication forks. These stalled replication forks then collapse to form one sided double-strand breaks, leading to apoptosis. However, colorectal cancer (CRC) stem cells rapidly repair the stalled/collapsed replication forks...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593639/ https://www.ncbi.nlm.nih.gov/pubmed/28915668 http://dx.doi.org/10.18632/oncotarget.19778 |