Long-term Administration of Nuclear Bile Acid Receptor FXR Agonist Prevents Spontaneous Hepatocarcinogenesis in Abcb4(−/−) Mice

Altered bile acid (BA) signaling is associated with hepatotoxicity. The farnesoid X receptor (FXR) is a nuclear receptor that transcriptionally regulates BA homeostasis. Mice with FXR ablation present hepatocarcinoma (HCC) due to high toxic BA levels. Mice with Abcb4 ablation accumulate toxic BA wit...

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Detalles Bibliográficos
Autores principales: Cariello, Marica, Peres, Claudia, Zerlotin, Roberta, Porru, Emanuele, Sabbà, Carlo, Roda, Aldo, Moschetta, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593831/
https://www.ncbi.nlm.nih.gov/pubmed/28894223
http://dx.doi.org/10.1038/s41598-017-11549-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593831/
https://www.ncbi.nlm.nih.gov/pubmed/28894223
http://dx.doi.org/10.1038/s41598-017-11549-7

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