Cargando…

Long-term Administration of Nuclear Bile Acid Receptor FXR Agonist Prevents Spontaneous Hepatocarcinogenesis in Abcb4(−/−) Mice

Altered bile acid (BA) signaling is associated with hepatotoxicity. The farnesoid X receptor (FXR) is a nuclear receptor that transcriptionally regulates BA homeostasis. Mice with FXR ablation present hepatocarcinoma (HCC) due to high toxic BA levels. Mice with Abcb4 ablation accumulate toxic BA wit...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cariello, Marica, Peres, Claudia, Zerlotin, Roberta, Porru, Emanuele, Sabbà, Carlo, Roda, Aldo, Moschetta, Antonio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593831/ https://www.ncbi.nlm.nih.gov/pubmed/28894223 http://dx.doi.org/10.1038/s41598-017-11549-7

Ejemplares similares

Intestinal FXR Activation via Transgenic Chimera or Chemical Agonism Prevents Colitis-Associated and Genetically-Induced Colon Cancer
por: Cariello, Marica, et al.
Publicado: (2022)

Suppression of Hepatic Bile Acid Synthesis by a non-tumorigenic FGF19 analogue Protects Mice from Fibrosis and Hepatocarcinogenesis
por: Gadaleta, Raffaella Maria, et al.
Publicado: (2018)

Transcriptional Regulation of Metabolic Pathways via Lipid-Sensing Nuclear Receptors PPARs, FXR, and LXR in NASH
por: Cariello, Marica, et al.
Publicado: (2021)

Adhesion of Platelets to Colon Cancer Cells Is Necessary to Promote Tumor Development in Xenograft, Genetic and Inflammation Models
por: Cariello, Marica, et al.
Publicado: (2021)

Corrigendum to ‘Fibroblast growth factor 19 modulates intestinal microbiota and inflammation in presence of farnesoid x receptor’: [EBioMedicine 54 (2020) 102719]
por: Gadaleta, Raffaella Maria, et al.
Publicado: (2020)

Fibroblast Growth Factor 19 modulates intestinal microbiota and inflammation in presence of Farnesoid X Receptor
por: Gadaleta, Raffaella Maria, et al.
Publicado: (2020)

LXRs, SHP, and FXR in Prostate Cancer: Enemies or Ménage à Quatre With AR?
por: Cariello, Marica, et al.
Publicado: (2018)

Bile Salt Hydrolase-Competent Probiotics in the Management of IBD: Unlocking the “Bile Acid Code”
por: Gadaleta, Raffaella Maria, et al.
Publicado: (2022)

Deciphering the nuclear bile acid receptor FXR paradigm
por: Modica, Salvatore, et al.
Publicado: (2010)

Proteomics for the discovery of nuclear bile acid receptor FXR targets()
por: Gardmo, Cissi, et al.
Publicado: (2011)

Extra Virgin Olive Oil: Lesson from Nutrigenomics
por: De Santis, Stefania, et al.
Publicado: (2019)

Platelets from patients with visceral obesity promote colon cancer growth
por: Cariello, Marica, et al.
Publicado: (2022)

Discovery, optimization, and evaluation of non-bile acid FXR/TGR5 dual agonists
por: Miyata, Sachiho, et al.
Publicado: (2021)

Hepatic Bile Acid Reuptake in the Rat Depends on Bile Acid Conjugation but Not on Agonistic Properties towards FXR and TGR5
por: Trammell, Samuel A. J., et al.
Publicado: (2020)

Role of Oleic Acid in the Gut-Liver Axis: From Diet to the Regulation of Its Synthesis via Stearoyl-CoA Desaturase 1 (SCD1)
por: Piccinin, Elena, et al.
Publicado: (2019)

AST to Platelet Ratio Index (APRI) is an easy-to-use predictor score for cardiovascular risk in metabolic subjects
por: De Matteis, Carlo, et al.
Publicado: (2021)

Fatty liver diseases, bile acids, and FXR
por: Zhu, Yan, et al.
Publicado: (2016)

Insights on FXR selective modulation. Speculation on bile acid chemical space in the discovery of potent and selective agonists
por: Sepe, Valentina, et al.
Publicado: (2016)

Effects of Bile Acids and the Bile Acid Receptor FXR Agonist on the Respiratory Rhythm in the In Vitro Brainstem Medulla Slice of Neonatal Sprague-Dawley Rats
por: Zhao, Cong, et al.
Publicado: (2014)

Serum Bile Acids Profiling in Inflammatory Bowel Disease Patients Treated with Anti-TNFs
por: Roda, Giulia, et al.
Publicado: (2019)

Monocyte-to-HDL Ratio (MHR) Predicts Vitamin D Deficiency in Healthy and Metabolic Women: A Cross-Sectional Study in 1048 Subjects
por: De Matteis, Carlo, et al.
Publicado: (2022)

Bile Acids, FXR, and Metabolic Effects of Bariatric Surgery
por: Noel, Olivier F., et al.
Publicado: (2016)

Bile Acids and FXR: Novel Targets for Liver Diseases
por: Stofan, Mary, et al.
Publicado: (2020)

Analysis of fecal bile acids and metabolites by high resolution mass spectrometry in farm animals and correlation with microbiota
por: Porru, Emanuele, et al.
Publicado: (2022)

Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Novel Non–Bile Acid FXR Agonist Tropifexor (LJN452) in Healthy Volunteers
por: Badman, Michael K., et al.
Publicado: (2019)

Bile acids and oxo-metabolites as markers of human faecal input in the ancient Pompeii ruins
por: Porru, Emanuele, et al.
Publicado: (2021)

Reduction in gut‐derived MUFAs via intestinal stearoyl‐CoA desaturase 1 deletion drives susceptibility to NAFLD and hepatocarcinoma
por: Ducheix, Simon, et al.
Publicado: (2022)

Impact of bile acids on the growth of human cholangiocarcinoma via FXR
por: Dai, Jiaqi, et al.
Publicado: (2011)

Bile acid nuclear receptor FXR and digestive system diseases
por: Ding, Lili, et al.
Publicado: (2015)

Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine
por: Wen, Jia, et al.
Publicado: (2021)

Role of bile acids in inflammatory bowel disease
por: Tiratterra, Elisa, et al.
Publicado: (2018)

Liver Capsule: FXR agonists against liver disease
por: Fuchs, Claudia D., et al.
Publicado: (2016)

Gut microbiota in the pathogenesis and therapeutic approaches of diabetes
por: Crudele, Lucilla, et al.
Publicado: (2023)

Identification of a Novel Score for Adherence to the Mediterranean Diet That Is Inversely Associated with Visceral Adiposity and Cardiovascular Risk: The Chrono Med Diet Score (CMDS)
por: De Matteis, Carlo, et al.
Publicado: (2023)

Metabolic Bile Acid Profile Impairments in Dogs Affected by Chronic Inflammatory Enteropathy
por: Comito, Rossana, et al.
Publicado: (2023)

Another One Bites the Gut: Nuclear Receptor LRH-1 in Intestinal Regeneration and Cancer
por: Zerlotin, Roberta, et al.
Publicado: (2021)

Optical control of the nuclear bile acid receptor FXR with a photohormone
por: Morstein, Johannes, et al.
Publicado: (2019)

Bile Acids, Microbiota, and Cystic Fibrosis: Channeling Intestinal FXR Signals
por: McHenry, Scott, et al.
Publicado: (2019)

Extra-Virgin Olive Oil from Apulian Cultivars and Intestinal Inflammation
por: Cariello, Marica, et al.
Publicado: (2020)

SUMOylation inhibitors synergize with FXR agonists in combating liver fibrosis
por: Zhou, Jiyu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_omu37a99p988cjp6nq2d8uc6dq