Cinaciguat ameliorates glomerular damage by reducing ERK1/2 activity and TGF-ß expression in type-1 diabetic rats

Decreased soluble guanylate cyclase activity and cGMP levels in diabetic kidneys were shown to influence the progression of nephropathy. The regulatory effects of soluble guanylate cyclase activators on renal signaling pathways are still unknown, we therefore investigated the renal molecular effects...

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Detalles Bibliográficos
Autores principales: Czirok, Szabina, Fang, Lilla, Radovits, Tamás, Szabó, Gábor, Szénási, Gábor, Rosivall, László, Merkely, Béla, Kökény, Gábor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593847/
https://www.ncbi.nlm.nih.gov/pubmed/28894114
http://dx.doi.org/10.1038/s41598-017-10125-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593847/
https://www.ncbi.nlm.nih.gov/pubmed/28894114
http://dx.doi.org/10.1038/s41598-017-10125-3

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