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p190RhoGAP proteins contain pseudoGTPase domains

The two p190RhoGAP proteins, p190RhoGAP-A and -B, are key regulators of Rho GTPase signaling and are essential for actin cytoskeletal structure and contractility. Here we report the discovery of two evolutionarily conserved GTPase-like domains located in the ‘middle domain’, previously thought to be...

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Detalles Bibliográficos
Autores principales: Stiegler, Amy L., Boggon, Titus J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593906/
https://www.ncbi.nlm.nih.gov/pubmed/28894085
http://dx.doi.org/10.1038/s41467-017-00483-x