Thrombin-derived host defence peptide modulates neutrophil rolling and migration in vitro and functional response in vivo

Host defence peptides (HDPs) derived from the C-terminus of thrombin are proteolytically generated by enzymes released during inflammation and wounding. In this work, we studied the effects of the prototypic peptide GKY25 (GKYGFYTHVFRLKKWIQKVIDQFGE), on neutrophil functions. In vitro, GKY25 was show...

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Detalles Bibliográficos
Autores principales: Lim, Chun Hwee, Puthia, Manoj, Butrym, Marta, Tay, Hui Min, Lee, Michelle Zi Yi, Hou, Han Wei, Schmidtchen, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593972/
https://www.ncbi.nlm.nih.gov/pubmed/28894159
http://dx.doi.org/10.1038/s41598-017-11464-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5593972/
https://www.ncbi.nlm.nih.gov/pubmed/28894159
http://dx.doi.org/10.1038/s41598-017-11464-x

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