Cargando…

Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells

BACKGROUND: Pancreatic cancer is generally acknowledged as the most common primary malignant tumor, and it is known to be resistant to conventional chemotherapy. Novel, selective antitumor agents are pressingly needed. METHODS: CCK-8 and colony formation assay were used to investigate the cell growt...

Descripción completa

Detalles Bibliográficos
Autores principales:	Xu, Zihang, Zhang, Fei, Bai, Chao, Yao, Chao, Zhong, Hairong, Zou, Chunpu, Chen, Xiao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5594456/ https://www.ncbi.nlm.nih.gov/pubmed/28893319 http://dx.doi.org/10.1186/s13046-017-0590-5

Ejemplares similares

Correction to: Sophoridine induces apoptosis and S phase arrest via ROS-dependent JNK and ERK activation in human pancreatic cancer cells
por: Xu, Zihang, et al.
Publicado: (2020)

Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation
por: Wong, Chew Hooi, et al.
Publicado: (2010)

Correction: Simultaneous Induction of Non-Canonical Autophagy and Apoptosis in Cancer Cells by ROS-Dependent ERK and JNK Activation
por: Wong, Chew Hooi, et al.
Publicado: (2016)

Studies on the Anti-Inflammatory Effect and Its Mechanisms of Sophoridine
por: Huang, Xiumei, et al.
Publicado: (2014)

Research Progress in the Pharmacological Activities, Toxicities, and Pharmacokinetics of Sophoridine and Its Derivatives
por: Tang, Qiong, et al.
Publicado: (2022)

Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma
por: Li, Bo, et al.
Publicado: (2020)

Sophoridine suppresses lenvatinib‐resistant hepatocellular carcinoma growth by inhibiting RAS/MEK/ERK axis via decreasing VEGFR2 expression
por: Zhao, Zhongwei, et al.
Publicado: (2020)

Erianin induces G2/M-phase arrest, apoptosis, and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo
por: Wang, H, et al.
Publicado: (2016)

Metformin induces cell cycle arrest, apoptosis and autophagy through ROS/JNK signaling pathway in human osteosarcoma: Erratum
por: Li, Bo, et al.
Publicado: (2022)

The Bioactive Extract of Pinnigorgia sp. Induces Apoptosis of Hepatic Stellate Cells via ROS-ERK/JNK-Caspase-3 Signaling
por: Kuo, Liang-Mou, et al.
Publicado: (2018)

Research progress of sophoridine’s pharmacological activities and its molecular mechanism: an updated review
por: Chen, Yiwei, et al.
Publicado: (2023)

Peiminine Induces G0/G1-Phase Arrest, Apoptosis, and Autophagy via the ROS/JNK Signaling Pathway in Human Osteosarcoma Cells in Vitro and in Vivo
por: Yu, Lei, et al.
Publicado: (2021)

Neochamaejasmin A Induces Mitochondrial-Mediated Apoptosis in Human Hepatoma Cells via ROS-Dependent Activation of the ERK1/2/JNK Signaling Pathway
por: Ding, Yangfang, et al.
Publicado: (2020)

Synergistic Apoptosis of CML Cells by Buthionine Sulfoximine and Hydroxychavicol Correlates with Activation of AIF and GSH-ROS-JNK-ERK-iNOS Pathway
por: Chowdhury, Avik Acharya, et al.
Publicado: (2013)

Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway
por: Li, Yu, et al.
Publicado: (2020)

Cypermethrin Induces Macrophages Death through Cell Cycle Arrest and Oxidative Stress-Mediated JNK/ERK Signaling Regulated Apoptosis
por: Huang, Fang, et al.
Publicado: (2016)

Sophoridine Inhibits the Tumour Growth of Non-Small Lung Cancer by Inducing Macrophages M1 Polarisation via MAPK-Mediated Inflammatory Pathway
por: Zhao, Bei, et al.
Publicado: (2021)

Longikaurin A, a natural ent-kaurane, induces G2/M phase arrest via downregulation of Skp2 and apoptosis induction through ROS/JNK/c-Jun pathway in hepatocellular carcinoma cells
por: Liao, Y-J, et al.
Publicado: (2014)

The ROS/JNK/ATF2 pathway mediates selenite-induced leukemia NB4 cell cycle arrest and apoptosis in vitro and in vivo
por: An, J J, et al.
Publicado: (2013)

Corrigendum: Non-esterified Fatty Acid Induce Dairy Cow Hepatocytes Apoptosis via the Mitochondria-Mediated ROS-JNK/ERK Signaling Pathway
por: Li, Yu, et al.
Publicado: (2020)

Sophoridine derivative 6j inhibits liver cancer cell proliferation via ATF3 mediated ferroptosis
por: Tian, Kunpeng, et al.
Publicado: (2023)

Actein induces autophagy and apoptosis in human bladder cancer by potentiating ROS/JNK and inhibiting AKT pathways
por: Ji, Lu, et al.
Publicado: (2017)

SYPL1 Inhibits Apoptosis in Pancreatic Ductal Adenocarcinoma via Suppression of ROS-Induced ERK Activation
por: Song, Yunda, et al.
Publicado: (2020)

Acacetin Induces Apoptosis in Human Osteosarcoma Cells by Modulation of ROS/JNK Activation
por: Wang, Shubin, et al.
Publicado: (2020)

Andrographolide induces apoptosis in human osteosarcoma cells via the ROS/JNK pathway
por: Wang, Shengdong, et al.
Publicado: (2020)

Tyrosol Prevents Ischemia/Reperfusion-Induced Cardiac Injury in H9c2 Cells: Involvement of ROS, Hsp70, JNK and ERK, and Apoptosis
por: Sun, Liwei, et al.
Publicado: (2015)

Sophoridine alleviates hyperalgesia and anxiety-like behavior in an inflammatory pain mouse model induced by complete freund’s adjuvant
por: Rong, Zheng, et al.
Publicado: (2023)

Libertellenone T, a Novel Compound Isolated from Endolichenic Fungus, Induces G2/M Phase Arrest, Apoptosis, and Autophagy by Activating the ROS/JNK Pathway in Colorectal Cancer Cells
por: Gamage, Chathurika D. B., et al.
Publicado: (2023)

ROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis
por: Shi, Y, et al.
Publicado: (2014)

Nonthermal Plasma Induces Apoptosis in ATC Cells: Involvement of JNK and p38 MAPK-Dependent ROS
por: Lee, Sei Young, et al.
Publicado: (2014)

Silibinin induces G1 arrest, apoptosis and JNK/SAPK upregulation in SW1990 human pancreatic cancer cells
por: Zhang, Xiaokai, et al.
Publicado: (2018)

Involvement of Nrf2-HO-1/JNK-Erk Signaling Pathways in Aconitine-Induced Developmental Toxicity, Oxidative Stress, and ROS-Mitochondrial Apoptosis in Zebrafish Embryos
por: Xia, Qing, et al.
Publicado: (2021)

Novel Sophoridine Derivatives Bearing Phosphoramide Mustard Moiety Exhibit Potent Antitumor Activities In Vitro and In Vivo
por: Li, Dongdong, et al.
Publicado: (2018)

Novel α, β-Unsaturated Sophoridinic Derivatives: Design, Synthesis, Molecular Docking and Anti-Cancer Activities
por: Xu, Yiming, et al.
Publicado: (2017)

ROS regulation of axonal mitochondrial transport is mediated by Ca(2+) and JNK in Drosophila
por: Liao, Pin-Chao, et al.
Publicado: (2017)

Nonylphenol Induces Apoptosis through ROS/JNK Signaling in a Spermatogonia Cell Line
por: Park, Hyun-Jung, et al.
Publicado: (2020)

Actin remodeling mediates ROS production and JNK activation to drive apoptosis-induced proliferation
por: Farrell, Luchi, et al.
Publicado: (2022)

Sophoridine exerts tumor-suppressive activities via promoting ESRRG-mediated β-catenin degradation in gastric cancer
por: Peng, Zhiyang, et al.
Publicado: (2020)

Betulinic Acid Induces ROS-Dependent Apoptosis and S-Phase Arrest by Inhibiting the NF-κB Pathway in Human Multiple Myeloma
por: Shen, Min, et al.
Publicado: (2019)

Rasfonin promotes autophagy and apoptosis via upregulation of reactive oxygen species (ROS)/JNK pathway
por: Wang, Weijun, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_rjb1dktntcuqk4t2sbgspvp0tu